August 2007

$11,501,024

Electro-Optical
Sciences, Inc.

Common Stock
and Warrants

July 2007

$18,002,500

pSivida Limited

Common Stock
and Warrants

June 2007

$20,004,972

Acusphere, Inc.

Common Stock
and Warrants

June 2007

$65,000,000

Athersys, Inc.

Reverse Merger
Common Stock
and Warrants

May 2007

$17,937,500

Silicom Limited

Common Stock
and Warrants

March 2007

$31,883,838

Iomai Corporation

Common Stock
and Warrants

February 2007

$45,500,000

Kosan Biosciences, Inc.

Common Stock

February 2007

$10,016,000

OccuLogix, Inc.

Common Stock
and Warrants

December 2006

$60,793,600

GTx, Inc.

Common Stock

December 2006

$24,999,999

Altair
Nanotechnologies, Inc.

Common Stock
and Warrants

December 2006

$80,000,000

Smith & Wesson
Holding Corporation

Senior Convertible
Notes

December 2006

$21,000,000

Javo Beverage
Company, Inc.

Senior Convertible
Notes and Warrants

December 2006

$35,999,990

Medivation, Inc.

Common Stock

December 2006

$25,462,949

Acusphere, Inc.

Common Stock
and Warrants

December 2006

$13,043,160

Dyadic
International, Inc.

Common Stock
and Warrants

November 2006

$14,038,934

Orchid Cellmark, Inc.

Common Stock

November 2006

$15,000,000

Biosensors
International
Group, Ltd.

Convertible Notes

November 2006

$168,000,000

CDC Corporation

Senior Exchangeable
Convertible Notes

November 2006

$11,419,200

PhotoMedex, Inc.

Common Stock
and Warrants

September 2006

$31,305,601

Bookham, Inc.

Common Stock
and Warrants

July 2006

$30,000,000

Bravo! Brands, Inc.

Senior Convertible Notes
and Warrants

July 2006

$52,500,000

Earth BioFuels, Inc.

Senior Convertible Notes
and Warrants

July 2006

$8,000,000

Micromet, Inc.

Common Stock
and Warrants

May 2006

$144,999,860

Pacific Ethanol, Inc.

Common Stock
and Warrants

May / June 2006

$20,000,000

Earth BioFuels, Inc.

Bridge Notes

May 2006

$28,550,000

Nestor, Inc.

Senior Convertible
Notes
and Warrants

May 2006

$45,000,000

Cyclacel
Pharmaceuticals Inc.

Common Stock
and Warrants

April 2006

$47,500,000

Cougar
Biotechnology, Inc.

Reverse Merger
Convertible Preferred Units

April 2006

€45,500,000

NiCox S.A.

Ordinary Shares

April 2006

$40,216,438

Acusphere, Inc.

Common Stock
and Warrants

March 2006

$40,000,003

Metabasis
Therapeutics, Inc.

Common Stock

March 2006

$48,000,156

CombinatoRx, Inc.

Common Stock

March 2006

$74,468,085

MRV
Communications, Inc.

Common Stock

March 2006

$45,000,001

Sunesis
Pharmaceuticals, Inc.

Common Stock
and Warrants

March 2006

$30,000,000

The Allied
Defense Group, Inc.

Convertible Notes
and Warrants

March 2006

$40,850,000

Genta Incorporated

Common Stock

February 2006

$40,105,002

YM Biosciences Inc.

Common Stock

February 2006

$29,999,984

EntreMed, Inc.

Common Stock
and Warrants

Janruary 2006

$14,410,000

InfoSonics Corporation

Common Stock
and Warrants

December 2005

$58,500,000

uBid.com, Inc.
Reverse Merger

Common Stock
and Warrants

December 2005

$17,500,000

Cambridge Display
Technology, Inc.

Common Stock
and Warrants

December 2005

$20,000,006

Discovery
Laboratories, Inc.

Common Stock

December 2005

$17,500,000

Halozyme
Therapeutics, Inc.

Common Stock

December 2005

$16,656,499

GTC
Biotherapeutics, Inc.

Common Stock
and Warrants

November 2005

$20,250,000

Bravo! Brands, Inc.

Common Stock
and Warrants

November 2005

$65,000,039

Solexa, Inc.

Common Stock
and Warrants

October 2005

$5,000,000

uBid.com, Inc.

Bridge Notes
and Warrants

October 2005

$40,000,000

Vasogen, Inc.

Senior Convertible
Notes
and Warrants

September 2005

$41,020,000

Metabasis
Therapeutics, Inc.

Common Stock
and Warrants

September 2005

$15,200,000

GenVec, Inc.

Common Stock

September 2005

$26,160,000

Smith & Wesson
Holding Corporation

Common Stock
and Warrants

August 2005

$31,237,500

Santarus, Inc.

Common Stock

August 2005

$12,500,000

Superconductor
Technologies, Inc.

Common Stock
and Warrants

August 2005

$17,499,990

WorldGate
Communications, Inc.

Common Stock
and Warrants

April 2005

Undisclosed

The Codemasters
Software Company Ltd.
Convertible
Preferred Stock

December 2004

$35,000,000

Penwest
Pharmaceuticals Co.

Common Stock

November 2004

$69,000,000

Global Power
Equipment Group Inc.

Convertible Notes

August 2004

$13,345,000

ISTA
Pharmaceuticals Inc.

Convertible Notes

July 2005

$35,000,000

Novavax, Inc.

Convertible Notes
and Common Stock

April 2004

$20,057,500

Cosi, Inc.

Common Stock